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Teclistamab for Patients with Heavily Pretreated Relapsed/Refractory Multiple Myeloma and Renal Impairment.

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Teclistamab for Patients with Heavily Pretreated Relapsed/Refractory Multiple Myeloma and Renal Impairment. Blood advances Dima, D., Afrough, A., Goel, U., Grajales-Cruz, A., Khouri, J., Julian, K., Pasvolsky, O., Banerjee, R., Razzo, B., Ferreri, C. J., Vazquez Martinez, M. A., Davis, J. A., Sannareddy, A., Castaneda Puglianini, O., Raza, S., Portuguese, A. J., Gaballa, M. R., Rana, M., Lieberman-Cribbin, A., DeJarnette, S., Gonzalez, R., Chen, A., Herr, M. M., Mikkilineni, L., Hosoya, H., Ouchveridze, E., Kaur, G., Rossi, A. C., Shune, L., Anwer, F., Lin, Y., Richard, S., Sborov, D. W., Baz, R. C., Garfall, A., Lee, H. C., Anderson, L. D., Cowan, A. J., Patel, K. K., Voorhees, P. M., Sidana, S., Hansen, D. K., Atrash, S., Susanibar-Adaniya, S. P. 2025

Abstract

Outcomes of bispecific antibodies in patients with renal impairment (RI) are not well-characterized given the exclusion of these patients from clinical trials. Herein, we evaluated patients with relapsed/refractory multiple myeloma and RI treated with standard-of-care teclistamab. RI was defined as creatinine clearance (CrCl) <40mL/min. CrCl <30mL/min or dialysis dependence were defined as severe RI. Of the 384 included patients, 81 (21%) had RI, including 45 (18%) with severe RI, and 18 (5%) on dialysis. Patients with RI were more likely to be older (median age 71 vs. 67 years, p=0.002), and have a higher median number of prior lines of therapy (7 vs. 6, p=0.04). Rates and severity of cytokine release syndrome (51% vs. 59%, grade =3: 1.2% vs. 1%) and immune effector cell-associated neurotoxicity syndrome (16% vs. 13%; grade =3: 2.5% vs 2.6%) were similar in patients with and without RI, respectively. Patients with RI had higher baseline and day-30 post-teclistamab grade =3 anemia and grade =3 thrombocytopenia. Renal function did not worsen after teclistamab initiation in patients with RI outside of the context of disease progression. Overall response rate (52% vs. 56%, p=0.61) and survival outcomes (median progression-free survival: 4.6 vs. 6.5 months; p=0.62) were comparable in patients with and without RI, respectively, after a median follow-up of 9.9 months. No differences in overall survival or non-relapse mortality were noted. Our findings suggest that treatment with teclistamab is feasible in patients with RI including those on dialysis, with a similar safety and efficacy profile to patients without RI.

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