New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. ÌýYou can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
WELCOME BACK
Intraepithelial ILC1-Like NK Cells Increase Lymphocyte Infiltration into the Tumor Microenvironment via the CXCL10 Axis.
À¶Ý®ÊÓƵ
Intraepithelial ILC1-Like NK Cells Increase Lymphocyte Infiltration into the Tumor Microenvironment via the CXCL10 Axis. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Maddineni, S., Sharma, K., Mohammad, I. A., Shin, J. H., Sunwoo, J. B. 2024Abstract
Intraepithelial type 1 innate lymphoid cells (ieILC1s) are tissue-resident lymphocytes in the microenvironment of head and neck squamous cell carcinoma. Here, we evaluate how these cells influence T-cell trafficking to tumors. We generated cytotoxic ieILC1-like cells from natural killer (NK) cells in vitro. Using an in vivo tumor model, we show that intratumoral ieILC1-like NK cells induce greater T cell trafficking into the tumor. Co-culture of ieILC1-like NK cells with the tumor cells resulted in elevated CXCL10 in the supernatant. Flow cytometry demonstrated that ieILC1-like NK cells produce robust amounts of IFNy, a known CXCL10 inducer, while CXCL10 was produced by tumor cells. These results indicate ieILC1-like NK cells induce tumor production of CXCL10, a proinflammatory chemokine that promotes T cell infiltration into the TME. The role of ieILC1-like NK cells in modulating clinical responses to immune checkpoint blockade warrants investigation.
View details for
View details for