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Pathophysiology of reduced glomerular filtration rate in delayed graft function
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Pathophysiology of reduced glomerular filtration rate in delayed graft function CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION Scandling, J. D., Myers, B. D. 1997; 6 (4): 405-409Abstract
Delayed graft function is a form of postischemic acute renal failure. It lowers glomerular filtration rate in large part by depressing the glomerular transcapillary hydraulic pressure difference, the driving force for the formation of filtrate. Loss of proximal tubule cell polarity, impaired sodium reabsorption and tubuloglomerular feedback-mediated afferent arteriolar constriction are all implicated. A link between delayed graft function and chronic allograft injury is evident. The ensuing impairment of graft survival makes urgent the need for further elucidation of delayed graft function and a search for an effective therapy.
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