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DELAYED TREATMENT WITH DEXTROMETHORPHAN AND DEXTRORPHAN REDUCES CEREBRAL-DAMAGE AFTER TRANSIENT FOCAL ISCHEMIA
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DELAYED TREATMENT WITH DEXTROMETHORPHAN AND DEXTRORPHAN REDUCES CEREBRAL-DAMAGE AFTER TRANSIENT FOCAL ISCHEMIA NEUROSCIENCE LETTERS Steinberg, G. K., Saleh, J., Kunis, D. 1988; 89 (2): 193-197Abstract
The N-methyl-D-aspartate (NMDA) antagonists dextromethorphan (DM) and dextrorphan (DX) were found to reduce significantly neocortical severe ischemic neuronal damage (SIND) when administered in a delayed fashion after the ischemic insult. Rabbits underwent occlusion of the left internal carotid artery and anterior cerebral artery for 1 h, followed by 4 h of reperfusion. Immediately after the completion of the 1 h arterial occlusion, animals were blindly treated intravenously with 20 mg/kg loading dose followed by 10 mg/kg/h of DM, 15 mg/kg loading dose followed by 15 mg/kg/h of DX, or an equivalent volume of normal saline (NS) alone. The area of neocortical SIND was 3.7% in the DM group, 4.4% in the DX group, and 41.3% in the normal saline controls. These drugs may have considerable therapeutic potential in clinical stroke.
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